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Longitudinal study on growth and body mass index before and after diagnosis of childhood craniopharyngioma

4 Inflammasome-mediated liver injury: DAMPs released from stressed hepatocytes, damaged mitochondria, and necrotic liver cells activate inflammasome sensors, triggering the oligomerization and activation of inflammasome components

In fact, the original description of regional ileitis by Crohn, Ginzburg, and Oppenheimer in 1932 states, The disease is clinically featured by symptoms that resemble those of ulcerative colitis, namely, fever, diarrhea, and emaciation (94) It is now understood that factors, including reduced food intake, malabsorption, and increased nutrient requirements, contribute to the development of malnutrition and nutrient deficiencies in IBD (95, 96) Up to 85% of patients experience some form of malnutrition, with both macronutrient and micronutrient being common